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Journal of Scientific Research and  Studies

Journal of Scientific Research and Studies Vol. 4(8), pp. 203-207, August, 2017

ISSN 2375-8791

Copyright 2017

Author(s) retain the copyright of this article


Full Length Research Paper

Feasibility study of deep-TMS add-on treatment for major depression in elderly patients


Daphna SHEFET1,2*, Iris IFAT1, Yiftach ROTH3 and Yechiel LEVKOVITZ2,4

1Shalvata Mental Health Center, Hod HaSharon, Israel.
2Tel Aviv University Sackler Faculty of Medicine, Tel Aviv, Israel.
3Ben Gurion University of the Negev, Be'er Sheva, Israel.
4Beer Yaacov & Ness-Ziona Mental Health Center, Ness-Ziona, Israel.

*Corresponding author. E-mail:

Accepted 21 August, 2017




Major depressive disorder (MDD) in the elderly is a major clinical problem. Depressed elderly subjects have shown modest antidepressant responses to transcranial magnetic stimulation (TMS) compared to younger adults. Deep TMS enables non-invasive stimulation of deep layers of the prefrontal cortex, and was approved for the treatment of MDD. The aim of this study was to examine the safety and efficacy of deep TMS add-on treatment for elderly MDD patients. Twenty daily H1-coil deep TMS treatments (18 Hz, 120% MT) were delivered in fifteen (15) elderly depressive patients. Clinical assessments were carried throughout the study and for an additional two weeks follow-up period. At the end of treatment period, there was a significant reduction on depression and anxiety rating scales. One subject reached remission and two reached response bordering remission. A trend toward significant improvement was found in the quality indicator disparity scale (QUIDS). At follow up, cognitive improvement was noted and treatment was well tolerated. In conclusion, an add-on H1-coil deep TMS treatment protocol in elderly MDD subjects indicated improvement in depressive symptoms.

Key words: Psychiatry, geriatric, affective disorders, depression, brain stimulation.

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Vol. 4 Issue 8

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