Scientific Research and Studies Vol. 4(8), pp. 203-207, August, 2017
Copyright © 2017
Author(s) retain the
copyright of this article
Full Length Research Paper
study of deep-TMS add-on treatment for major depression in
Daphna SHEFET1,2*, Iris IFAT1, Yiftach ROTH3
and Yechiel LEVKOVITZ2,4
1Shalvata Mental Health
Center, Hod HaSharon, Israel.
2Tel Aviv University – Sackler Faculty of Medicine, Tel Aviv, Israel.
3Ben Gurion University of the Negev, Be'er Sheva, Israel.
4Beer Yaacov & Ness-Ziona Mental Health Center, Ness-Ziona, Israel.
*Corresponding author. E-mail:
Accepted 21 August, 2017
Major depressive disorder (MDD) in the elderly is a major
clinical problem. Depressed elderly subjects have shown modest
antidepressant responses to transcranial magnetic stimulation
(TMS) compared to younger adults. Deep TMS enables non-invasive
stimulation of deep layers of the prefrontal cortex, and was
approved for the treatment of MDD. The aim of this study was to
examine the safety and efficacy of deep TMS add-on treatment for
elderly MDD patients. Twenty daily H1-coil deep TMS treatments
(18 Hz, 120% MT) were delivered in fifteen (15) elderly
depressive patients. Clinical assessments were carried
throughout the study and for an additional two weeks follow-up
period. At the end of treatment period, there was a significant
reduction on depression and anxiety rating scales. One subject
reached remission and two reached response bordering remission.
A trend toward significant improvement was found in the quality
indicator disparity scale (QUIDS). At follow up, cognitive
improvement was noted and treatment was well tolerated. In
conclusion, an add-on H1-coil deep TMS treatment protocol in
elderly MDD subjects indicated improvement in depressive
Key words: Psychiatry, geriatric, affective disorders,
depression, brain stimulation.
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