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Journal of Scientific Research and  Studies

Journal of Scientific Research and Studies Vol. 4(11), pp. 293-303, November, 2017

ISSN 2375-8791

Copyright © 2017

Author(s) retain the copyright of this article

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Full Length Research Paper

Evaluation of liver fibrosis index calculated by strain elastography for assessment of liver fibrosis in chronic viral hepatitis

 

Daniel Doykov*, Vladimir Andonov and Uswah Asif

Second Department of Internal Diseases, Medical University of Plovdiv, Gastroenterology Clinic, University Hospital, Kaspela, 64 Sofia str, Plovdiv 4001, Bulgaria.

 

*Corresponding author. E-mail: daniel_doykov@abv.bg, Tel: 00359887375459
 

Accepted 21 November, 2017

 

 Abstract

 

The accurate measurement of the liver fibrosis is important for the decision in the treatment of chronic viral hepatitis. The various types of ultrasound elastography are relatively well studied. Transient elastography (TE) and shear wave elastography (SWE) are proven methods of assessment of liver stiffness and possess the properties of a prognostic indicator. In contrast to this method, the significance of strain elastography used to assess the degree of liver stiffness remains insufficiently established. In this study, RT elastography was conducted in 144 patients. 34 of them were with chronic viral Hepatitis C, 80 with chronic viral Hepatitis B and 30 healthy individuals as control group. The biomarkers APRI, Fibroindex, Fornís index, FIB-4, and Fibrotest were examined. In all patients outside of the control group, a liver biopsy was performed for histological evaluation of fibrosis. The RT-generated elastographic imaging was subjected to qualitative analysis by a specially developed program and the derived liver fibrosis index (LFI) was compared to histological and laboratory data. The value of LFI increases as fibrosis progresses. LFI is significantly different in the cases of moderate fibrosis (F0-2) and advanced fibrosis (F3, 4). LFI shows a good correlation in determining advanced fibrosis and good reproducibility of the results. LFI was found to be an independent prognostic factor in patients with chronic liver disease. Strain elastography can be used to determine advanced liver fibrosis without influence of hepatic inflammation, unlike other serology markers of liver fibrosis. RTE is probably a prognostic factor in chronic liver diseases.

Key words: Real-time liver elastography, strain liver elastography, liver stiffness.

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