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Journal of Scientific Research and  Studies

Journal of Scientific Research and Studies Vol. 5(3), pp. 65-72, March, 2018

ISSN 2375-8791

Copyright © 2018

Author(s) retain the copyright of this article

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Full Length Research Paper

Medical ozone prevents inflammatory effects from carrageenan-induced knee joint synovitis in rats through A1 adenosine receptor, as well as lipid and protein oxidative damages

 

Gabriel Takon Oru1, Renate Viebhan-Haensler2, Yanet Hernández Matos1, Daylin Díaz Rodríguez3, Mayté Casanova  Orta1 and Olga Sonia León Fernández1*

1Pharmacy and Food Institute, University of Havana, Havana 10 400, Cuba.
2Medical Society for the Use of Ozone in Prevention and Therapy, Iffezheim/Baden-Baden D-76473, Germany.
3Center for Control of Drug and Medical Devices (CECMED), Ministry of Public Health, Havana 10 300, Cuba.
 

*Corresponding author. E-mail: olga@infomed.sld.cu, Tel: (537) 7 272 77 26

Accepted 22 March, 2018

 

 Abstract

 

Medical ozone reduced inflammation, IL-1β, TNF-α mRNA levels and oxidative stress in experimental arthritis. The aim of this study was to investigate whether medical ozone could reduce inflammation through A1 adenosine receptor, as well as by decreasing oxidative stress in carrageenan-induced knee joint synovitis. Wistar rats were used for the study. Synovitis was induced by 50 µl intra-articular injection of 3% carrageenan. The joint inflammation, the histopathological characterization of knee joint and redox markers in supernatants of spleen homogenates were determined. In order to evaluate the role of A1 adenosine receptor, 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) was tested. The results show that medical ozone prevented inflammation, reduced cell infiltration, and protected against oxidative protein damage and lipid peroxidation. DPCPX counteracted the protective effects of ozone. In conclusion, medical ozone protected against the inflammatory response in experimental synovitis. The protective effects of ozone involved A1 adenosine receptor activity and the control of oxidative injury to biomolecules.

Key words: Ozone, inflammation, adenosine, oxidative stress.

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