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Journal of
Scientific Research and Studies Vol. 9(1), pp. 1-7, February, 2022
ISSN 2375-8791
Copyright © 2022
Author(s) retain the
copyright of this article
http://www.modernrespub.org/jsrs/index.htm
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Full Length Research Paper
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Activity against
Leishmania sp. (Trypanosomatidae) of
8β-isovalerianyloxy-9α-hydroxy-calyculatolide isolated from
Neurolaena lobata (Astereceae) in Costa Rica
Vanessa Bagnarello-Madrigal2,4*, Alonso Calvo-Vargas1,
Misael Chinchilla-Carmona2, Idalia Valerio-Campos2,5,
Ronald Sánchez-Porras3 and Jose Bolaños-Jiménez2
1Department of Chemistry,
Universidad de Ciencias Médicas (UCIMED), San José, Costa Rica.
2Department of Basic Research, Universidad de Ciencias Médicas (UCIMED),
San José, Costa Rica.
3Section of Biology, Campus of the West, Universidad de Costa Rica,
San José, Costa Rica.
4School of Physiotherapy, University of Medical Sciences (UCIMED),
San José, Costa Rica.
5Faculty of Microbiology, University of Medical Sciences (UCIMED),
San José, Costa Rica.
*Corresponding author.
E-mail:
bagnarellomv@ucimed.com
Accepted 11 February, 2022
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Abstract |
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Neurolaena lobata
(Astereceae) has a variety of uses in traditional medicine,
including the treatment of protozoan infections, ulcers,
diabetes and inflammatory skin disorders. The therapeutic
properties are mainly attributed to the sesquiterpene lactones
produced by N. lobata (Astereceae). In this study,
8β-isovalerianyloxy-9α-hydroxy-calyculatolide, a
sesquiterpene lactone present in the mature leaves of N.
lobata, was isolated. The compound was characterized by
spectroscopic techniques with an IC50 value of 3.75 ±
1.63 µg/mL against Leishmania sp in in vitro
tests. This study emphasizes the importance of identifying the
components responsible for the biological activities of
plant-based treatments. Such knowledge is vital for the
standardization and development of phytopharmaceuticals.
Key words:
Neurolaena lobata,
sesquiterpene lactones, in vitro, Leishmania sp.,
phytochemical screening, Costa Rica. |
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Other Journal
■ Modern Research Journal of
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